Yes, although not that easily. One of the selling points of folding fatbikes is their enhanced portability. Folding them potentially makes it easier to carry them in a car without a bike rack. But the ebikes are still heavy, bulky, and take up a lot of space.
On the new (2014+) Jeep Cherokees, the hatch opening is narrow, compared to similar-sized SUVs, and the cargo floor is only 36.1 inches wide between the wheelwells. Even when it’s folded in half, it’s nearly impossible to fit the Radpower Radmini in without putting down the back seats. On its side, the bike takes up most of the cargo area. The low ceiling means you risk scratching the headliner if you put it in upright, although once it’s in, you could probably squeeze a second folded e-bike alongside it. Most of the scratches on my Radmini – and all the scratches in the back of the Jeep – are from loading and unloading the bike.
The official dimensions of the 2019 Jeep Cherokee cargo area are 25.8 cubic feet behind the rear seats and 54.7 cu ft with the second row folded down. That’s less than the otherwise similar-sized Subaru Forester, which has 28.9 and 70.9 cu ft of space, respectively, behind the second row and first row seats.